Prevalence and Antibiotic Susceptibility Patterns of Selected Bacterial Uropathogens Among Patients With Urinary Tract Infection Cases in Wonji Hospital, Ethiopia’

Prevalence and Antibiotic Susceptibility Patterns of Selected Bacterial Uropathogens Among Patients With Urinary Tract Infection Cases in Wonji Hospital, Ethiopia’

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Title: Prevalence and Antibiotic Susceptibility Patterns of Selected Bacterial Uropathogens Among Patients With Urinary Tract Infection Cases in Wonji Hospital, Ethiopia’
Author: Erifo Hibore, Mulugeta; Kebede, Dr. Ameha
Abstract: This study was conducted from February to April 2012 to determine the prevalence, risk factors and antibiotic susceptibility patterns of selected bacterial uropathogens among patients with urinary tract infection (UTI) cases in Wonji Hospital, Ethiopia. A hospital-based cross-sectional survey was conducted to assess the risk factors of UTI. In addition, laboratory based work was conducted to determine the prevalence and antibiotic susceptibility patterns of gram-negative and gram-positive bacterial uropathogens using standard procedures. The isolates were identified based on their morphological and biochemical characteristics. The identified bacterial uropathogens were subsequently exposed to selected antibiotics to test for development of resistance using the Kirby-Bauer disc diffusion method. The results of the study revealed that the prevalence of Gram-negative uropathogens (27.34 %) was higher than that of Gram-positive uropathogens (25.26 %). Among these pathogens, E. coli (22.4 %) was the most dominant uropathogen, followed by S. saprophyticus (17.45%). Next to these two, S. aureus, K. pneumoniae and S. epidermidis were found in 5.4 %, 4.9 % and 2.3 % of the total samples examined, respectively. The prevalence of E.coli and S.saprophyticus also varied with marital status. Out of 86 E. coli isolates, 63.93 % and 33.72 % were in the age group of 19-39 years and 40-59 years, respectively. Similarly, the prevalence of S. saprophyticus within these age groups was high.Very high prevalence of UTI was observed amongst the married females within the age range of between 19 - 59 years than males . All the isolates showed greater sensitivity for nitrofurantoin , ciprofloxacin , trimethoprim – Sulfamethoxazole and nalidixic acid, respectively. However, they were also highly resistant to ampicillin, amoxicillin and gentamycin. S. saprophyticus isolates were 100% resistant to novobiocin, but they showed high sensitivity for nitrofurantoin (89.55 %), trimethoprim-sulfamethoxazole (82.09 %) and ciprofloxacin (80.59 % ). 100 % of the S. aureus isolates were sensitive to both nitrofurantoin and novobiocinin in addition to showing 85.71 % and 76.19 % sensitivity for nalidixic acid and chloramphenicol, respectively.S.epidermidis isolates were also 100 % sensitive to novobiocin,nitrofurantoin and trimethoprim-sulfamethoxazole .Moreover, all of the isolates have developed multi-drug resistance. The isolates have showed 55.45 % ,54.23 % and 49 % resistance to amoxicillin , ampicillin and tetracycline , respectively .Thus , on the basis of the findings ,nitrofurantoin , ciprofloxacin , trimethoprim - sulfamethoxazole and nalidixic acid may be selected as drugs of choice in the area. Frequent sexual activity is the risk factors that had significant association with the prevalence of most uropathogens.
Description: 86p.
URI: http://hdl.handle.net/123456789/3261
Date: 2012-08


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